Defining HIV-1 Vif residues that interact with CBFβ by site-directed mutagenesis

Vif is essential for HIV-1 replication in T cells and macrophages. Vif recruits a host ubiquitin ligase complex to promote proteasomal degradation of the APOBEC3 restriction factors by poly-ubiquitination. The cellular transcription cofactor CBFβ is required for Vif function by stabilizing the Vif p...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Matsui, Yusuke, Shindo, Keisuke, Nagata, Kayoko, Io, Katsuhiro, Tada, Kohei, Iwai, Fumie, Kobayashi, Masayuki, Kadowaki, Norimitsu, Harris, Reuben S, Takaori-Kondo, Akifumi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936105/
https://ncbi.nlm.nih.gov/pubmed/24418540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.11.004
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