APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobuli...

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Bibliographische Detailangaben
Hauptverfasser: Shinohara, Masanobu, Io, Katsuhiro, Shindo, Keisuke, Matsui, Masashi, Sakamoto, Takashi, Tada, Kohei, Kobayashi, Masayuki, Kadowaki, Norimitsu, Takaori-Kondo, Akifumi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3496164/
https://ncbi.nlm.nih.gov/pubmed/23150777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep00806
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