Small molecules that inhibit Vif-induced degradation of APOBEC3G

BACKGROUND: HIV-1 Vif is essential for virus replication in natural target cells such as T cells and macrophages. Vif recruits a ubiquitin ligase to degrade restrictive APOBEC3 proteins. APOBEC3G is one of the most potent retroviral restriction factors targeted by Vif and, as such, the Vif-APOBEC3G...

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Bibliografiske detaljer
Main Authors: Matsui, Masashi, Shindo, Keisuke, Izumi, Taisuke, Io, Katsuhiro, Shinohara, Masanobu, Komano, Jun, Kobayashi, Masayuki, Kadowaki, Norimitsu, Harris, Reuben S, Takaori-Kondo, Akifumi
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4085377/
https://ncbi.nlm.nih.gov/pubmed/24986077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-11-122
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