The PTEN pathway in T(regs) is a critical driver of the suppressive tumor microenvironment

The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (T(reg)) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. PTEN acted to stabilize...

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Publicado en:Sci Adv
Autores principales: Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640592/
https://ncbi.nlm.nih.gov/pubmed/26601142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500845
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