The PTEN pathway in T(regs) is a critical driver of the suppressive tumor microenvironment

The tumor microenvironment is profoundly immunosuppressive. We show that multiple tumor types create intratumoral immune suppression driven by a specialized form of regulatory T cell (T(reg)) activation dependent on the PTEN (phosphatase and tensin homolog) lipid phosphatase. PTEN acted to stabilize...

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Udgivet i:Sci Adv
Main Authors: Sharma, Madhav D., Shinde, Rahul, McGaha, Tracy L., Huang, Lei, Holmgaard, Rikke B., Wolchok, Jedd D., Mautino, Mario R., Celis, Esteban, Sharpe, Arlene H., Francisco, Loise M., Powell, Jonathan D., Yagita, Hideo, Mellor, Andrew L., Blazar, Bruce R., Munn, David H.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2015
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640592/
https://ncbi.nlm.nih.gov/pubmed/26601142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1500845
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