A Randomized, Placebo-Controlled Study of SRT2104, a SIRT1 Activator, in Patients with Moderate to Severe Psoriasis

Activation of Sirtuin (silent mating type information regulation 2 homolog) 1, or SIRT1, is an unexplored therapeutic approach for treatment of inflammatory diseases. We randomized 40 patients with moderate-to-severe psoriasis (4:1) to three escalating doses of SRT2104, a selective activator of SIRT...

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Sparad:
Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Krueger, James G., Suárez-Fariñas, Mayte, Cueto, Inna, Khacherian, Artemis, Matheson, Robert, Parish, Lawrence C., Leonardi, Craig, Shortino, Denise, Gupta, Akanksha, Haddad, Jonathan, Vlasuk, George P., Jacobson, Eric W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4640558/
https://ncbi.nlm.nih.gov/pubmed/26556603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0142081
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