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Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors
Cellular causes of resistance and limited drug distribution within solid tumors limit therapeutic efficacy of anticancer drugs. Acidic endosomes in cancer cells mediate autophagy, which facilitates survival of stressed cells, and may contribute to drug resistance. Basic drugs (e.g. doxorubicin) are...
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| Published in: | Cancer Sci |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
John Wiley & Sons, Ltd
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4638015/ https://ncbi.nlm.nih.gov/pubmed/26212113 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.12756 |
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