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The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors

BACKGROUND: Anti-cancer drugs access solid tumors via blood vessels, and must penetrate tumor tissue to reach all cancer cells. Previous studies have demonstrated steep gradients of decreasing doxorubicin fluorescence with increasing distance from blood vessels, such that many tumor cells are not ex...

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Bibliografiske detaljer
Main Authors: Patel, Krupa J, Tannock, Ian F
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770566/
https://ncbi.nlm.nih.gov/pubmed/19807929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-356
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