Proton pump inhibitor Lansoprazole is a nuclear Liver X Receptor agonist

The liver X receptors (LXRα and LXRβ) are transcription factors that control the expression of genes primarily involved in cholesterol metabolism. In brain, in addition to normal neuronal function, cholesterol metabolism is important for APP proteolytic cleavage, secretase activities, Aβ aggregation...

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Bibliographic Details
Main Authors: Cronican, Andrea A., Fitz, Nicholas F., Pham, Tam, Fogg, Allison, Kifer, Brionna, Koldamova, Radosveta, Lefterov, Iliya
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834822/
https://ncbi.nlm.nih.gov/pubmed/20060385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.12.018
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