Proton pump inhibitor Lansoprazole is a nuclear Liver X Receptor agonist

The liver X receptors (LXRα and LXRβ) are transcription factors that control the expression of genes primarily involved in cholesterol metabolism. In brain, in addition to normal neuronal function, cholesterol metabolism is important for APP proteolytic cleavage, secretase activities, Aβ aggregation...

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Hlavní autoři: Cronican, Andrea A., Fitz, Nicholas F., Pham, Tam, Fogg, Allison, Kifer, Brionna, Koldamova, Radosveta, Lefterov, Iliya
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2834822/
https://ncbi.nlm.nih.gov/pubmed/20060385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.12.018
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