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Proton pump inhibitor Lansoprazole is a nuclear Liver X Receptor agonist
The liver X receptors (LXRα and LXRβ) are transcription factors that control the expression of genes primarily involved in cholesterol metabolism. In brain, in addition to normal neuronal function, cholesterol metabolism is important for APP proteolytic cleavage, secretase activities, Aβ aggregation...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2834822/ https://ncbi.nlm.nih.gov/pubmed/20060385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2009.12.018 |
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