Practical impacts of genomic data “cleaning” on biological discovery using surrogate variable analysis

BACKGROUND: Genomic data production is at its highest level and continues to increase, making available novel primary data and existing public data to researchers for exploration. Here we explore the consequences of “batch” correction for biological discovery in two publicly available expression dat...

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Vydáno v:BMC Bioinformatics
Hlavní autoři: Jaffe, Andrew E., Hyde, Thomas, Kleinman, Joel, Weinbergern, Daniel R., Chenoweth, Joshua G., McKay, Ronald D., Leek, Jeffrey T., Colantuoni, Carlo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636836/
https://ncbi.nlm.nih.gov/pubmed/26545828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0808-5
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