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Practical impacts of genomic data “cleaning” on biological discovery using surrogate variable analysis

BACKGROUND: Genomic data production is at its highest level and continues to increase, making available novel primary data and existing public data to researchers for exploration. Here we explore the consequences of “batch” correction for biological discovery in two publicly available expression dat...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Jaffe, Andrew E., Hyde, Thomas, Kleinman, Joel, Weinbergern, Daniel R., Chenoweth, Joshua G., McKay, Ronald D., Leek, Jeffrey T., Colantuoni, Carlo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4636836/
https://ncbi.nlm.nih.gov/pubmed/26545828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-015-0808-5
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