Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses

Adjuvants for DNA vaccination are designed to promote transformation of transgenes into target cells and increase inflammation in the site of injection, with resultant immune cell recruitment. Numerous studies indicated cationic liposomes as effective adjuvants for DNA vaccination due to their abili...

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Bibliographic Details
Published in:Hum Vaccin Immunother
Main Authors: Rose, Aaron H, Hoffmann, FuKun W, Hara, Jared H, Urschitz, Johann, Moisyadi, Stefan, Hoffmann, Peter R, Bertino, Pietro
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635848/
https://ncbi.nlm.nih.gov/pubmed/26091088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2015.1047567
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