Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses

DNA vaccination with plasmid has conventionally involved vectors designed for transient expression of antigens in injected tissues. Next generation plasmids are being developed for site-directed integration of transgenes into safe sites in host genomes and may provide an innovative approach for stab...

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Bibliografiske detaljer
Main Authors:	Bertino, Pietro, Urschitz, Johann, Hoffmann, FuKun W., You, Bo Ra, Rose, Aaron H., Park, Woo Hyun, Moisyadi, Stefan, Hoffmann, Peter R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	2014
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3973154/ https://ncbi.nlm.nih.gov/pubmed/24513010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.01.063
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Vaccination with a piggyBac plasmid with transgene integration potential leads to sustained antigen expression and CD8(+) T cell responses

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