Calpain-2 inhibitor therapy reduces murine colitis and colitis associated cancer

BACKGROUND: An important role has emerged for calpain enzymes in regulating inflammation with one isoform, calpain-2, particularly important for macrophage activation. The goal of this study was to determine the therapeutic potential of a synthetic calpain-2 inhibitor, zLLY-CH2F, for colitis and inf...

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Bibliographic Details
Published in:Inflamm Bowel Dis
Main Authors: Rose, Aaron H., Huang, Zhi, Mafnas, Chrisy, Hara, Jared H., Hoffmann, FuKun W., Hashimoto, Ann S., Bertino, Pietro, Hoffmann, Peter R.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540674/
https://ncbi.nlm.nih.gov/pubmed/26076056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MIB.0000000000000471
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