A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters

Clostridium difficile is the major cause of hospital-acquired infectious diarrhea and colitis in developed countries. The pathogenicity of C. difficile is mainly mediated by the release of 2 large potent exotoxins, toxin A (TcdA) and toxin B (TcdB), both of which require neutralization to prevent di...

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Detalhes bibliográficos
Publicado no:Hum Vaccin Immunother
Main Authors: Wang, Yuan-Kai, Yan, Ya-Xian, Kim, Hyeun Bum, Ju, Xianghong, Zhao, Song, Zhang, Keshan, Tzipori, Saul, Sun, Xingmin
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4635733/
https://ncbi.nlm.nih.gov/pubmed/26036797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21645515.2015.1052352
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