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Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-α by macrophages

Clostridium difficile causes serious and potentially fatal inflammatory diseases of the colon. Two large protein toxins, TcdA and TcdB, have been clearly implicated in pathogenesis. The goal of this study was to determine whether the glucosyltransferase activity of the toxins is critical for the ind...

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Detalhes bibliográficos
Main Authors: Sun, Xingmin, He, Xiangyun, Tzipori, Saul, Gerhard, Ralf, Feng, Hanping
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692465/
https://ncbi.nlm.nih.gov/pubmed/19324080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.micpath.2009.03.002
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