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Germline BAP1 mutation in a family with high incidence of multiple primary cancers and a potential gene-environment interaction

We report a high-risk cancer family with multiple mesotheliomas, cutaneous melanomas, basal cell carcinomas, and meningiomas segregating with a germline nonsense mutation in BAP1 (c.1938T>A; p.Y646X). Notably, most (four of five) mesotheliomas were peritoneal rather than the usually more common p...

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Publicat a:Cancer Lett
Autors principals: Cheung, Mitchell, Kadariya, Yuwaraj, Talarchek, Jacqueline, Pei, Jianming, Ohar, Jill A., Kayaleh, Omar R., Testa, Joseph R.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4634709/
https://ncbi.nlm.nih.gov/pubmed/26409435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2015.09.011
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