LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair

Leukemia/lymphoma-related factor (LRF) is a POZ/BTB and Krüppel (POK) transcriptional repressor characterized by context-dependent key roles in cell fate decision and tumorigenesis. Here we demonstrate an unexpected transcription-independent function for LRF in the classical non-homologous end joini...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Liu, Xue-Song, Chandramouly, Gurushankar, Rass, Emilie, Guan, Yinghua, Wang, Guocan, Hobbs, Robin M., Rajendran, Anbazhagan, Xie, Anyong, Shah, Jagesh V., Davis, Anthony J., Scully, Ralph, Lunardi, Andrea, Pandolfi, Pier Paolo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Pub. Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4633636/
https://ncbi.nlm.nih.gov/pubmed/26446488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9325
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