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Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells

Ataxia telangiectasia mutated (ATM) is activated upon DNA double strand breaks (DSBs) and phosphorylates numerous DSB response proteins, including histone H2AX on serine 139 (Ser-139) to form γ-H2AX. Through interaction with MDC1, γ-H2AX promotes DSB repair by homologous recombination (HR). H2AX Ser...

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書誌詳細
主要な著者: Rass, Emilie, Chandramouly, Gurushankar, Zha, Shan, Alt, Frederick W., Xie, Anyong
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591618/
https://ncbi.nlm.nih.gov/pubmed/23355489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445825
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