Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells

Ataxia telangiectasia mutated (ATM) is activated upon DNA double strand breaks (DSBs) and phosphorylates numerous DSB response proteins, including histone H2AX on serine 139 (Ser-139) to form γ-H2AX. Through interaction with MDC1, γ-H2AX promotes DSB repair by homologous recombination (HR). H2AX Ser...

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Bibliografiske detaljer
Main Authors: Rass, Emilie, Chandramouly, Gurushankar, Zha, Shan, Alt, Frederick W., Xie, Anyong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2013
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591618/
https://ncbi.nlm.nih.gov/pubmed/23355489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445825
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