Ataxia Telangiectasia Mutated (ATM) Is Dispensable for Endonuclease I-SceI-induced Homologous Recombination in Mouse Embryonic Stem Cells

Ataxia telangiectasia mutated (ATM) is activated upon DNA double strand breaks (DSBs) and phosphorylates numerous DSB response proteins, including histone H2AX on serine 139 (Ser-139) to form γ-H2AX. Through interaction with MDC1, γ-H2AX promotes DSB repair by homologous recombination (HR). H2AX Ser...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Rass, Emilie, Chandramouly, Gurushankar, Zha, Shan, Alt, Frederick W., Xie, Anyong
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2013
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591618/
https://ncbi.nlm.nih.gov/pubmed/23355489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.445825
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