Inhibition of gene expression by triple helix-directed DNA cross-linking at specific sites.

Synthetic oligodeoxynucleotides represent promising tools for gene inhibition in live systems. Triple helix-forming oligonucleotides, which bind to double-stranded DNA, are of special interest since they are targeted to the gene itself rather than to its mRNA product, as in the antisense strategy. T...

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Main Authors: Grigoriev, M, Praseuth, D, Guieysse, A L, Robin, P, Thuong, N T, Hélène, C, Harel-Bellan, A
Format: Artigo
Jezik:Inglês
Izdano: 1993
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC46328/
https://ncbi.nlm.nih.gov/pubmed/8475098
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