Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones

ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Open Biol
Main Authors: Skouloubris, Stéphane, Djaout, Kamel, Lamarre, Isabelle, Lambry, Jean-Christophe, Anger, Karine, Briffotaux, Julien, Liebl, Ursula, de Reuse, Hilde, Myllykallio, Hannu
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632503/
https://ncbi.nlm.nih.gov/pubmed/26040760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150015
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker