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Mechanism of Naphthoquinone Selectivity of Thymidylate Synthase ThyX

Naphthoquinones (NQs) are natural and synthetic compounds with a wide range of biological activities commonly attributed to their redox activity and/or chemical reactivity. However, genetic and biochemical experiments have recently demonstrated that 2-hydroxy-NQs (2-OH-NQs) act as highly specific no...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Myllykallio, Hannu, Becker, Hubert F., Aleksandrov, Alexey
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7822743/
https://ncbi.nlm.nih.gov/pubmed/33217379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2020.10.042
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