Mechanistic and structural basis for inhibition of thymidylate synthase ThyX

Nature has established two mechanistically and structurally unrelated families of thymidylate synthases that produce de novo thymidylate or dTMP, an essential DNA precursor. Representatives of the alternative flavin-dependent thymidylate synthase family, ThyX, are found in a large number of microbia...

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Detalhes bibliográficos
Main Authors: Basta, Tamara, Boum, Yap, Briffotaux, Julien, Becker, Hubert F., Lamarre-Jouenne, Isabelle, Lambry, Jean-Christophe, Skouloubris, Stephane, Liebl, Ursula, Graille, Marc, van Tilbeurgh, Herman, Myllykallio, Hannu
Formato: Artigo
Idioma:Inglês
Publicado em: The Royal Society 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3498832/
https://ncbi.nlm.nih.gov/pubmed/23155486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.120120
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