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Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX

In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride donor. Because all three substrates bind in close proximity to the catalytic flavin adenine dinucleotide...

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Bibliografische gegevens
Hoofdauteurs: Laptenok, Sergey P., Bouzhir-Sima, Latifa, Lambry, Jean-Christophe, Myllykallio, Hannu, Liebl, Ursula, Vos, Marten H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2013
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670337/
https://ncbi.nlm.nih.gov/pubmed/23671075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218729110
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