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Ultrafast real-time visualization of active site flexibility of flavoenzyme thymidylate synthase ThyX
In many bacteria the flavoenzyme thymidylate synthase ThyX produces the DNA nucleotide deoxythymidine monophosphate from dUMP, using methylenetetrahydrofolate as carbon donor and NADPH as hydride donor. Because all three substrates bind in close proximity to the catalytic flavin adenine dinucleotide...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3670337/ https://ncbi.nlm.nih.gov/pubmed/23671075 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218729110 |
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