Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

There is an urgent need to identify new treatments for tuberculosis (TB), a major infectious disease caused by Mycobacterium tuberculosis (Mtb), which results in 1.5 million deaths each year. We have targeted two essential enzymes in this organism that are promising for antibacterial therapy and rep...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Djaout, Kamel, Singh, Vinayak, Boum, Yap, Katawera, Victoria, Becker, Hubert F., Bush, Natassja G., Hearnshaw, Stephen J., Pritchard, Jennifer E., Bourbon, Pauline, Madrid, Peter B., Maxwell, Anthony, Mizrahi, Valerie, Myllykallio, Hannu, Ekins, Sean
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4901301/
https://ncbi.nlm.nih.gov/pubmed/27283217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27792
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