Targeting of Helicobacter pylori thymidylate synthase ThyX by non-mitotoxic hydroxy-naphthoquinones

ThyX is an essential thymidylate synthase that is mechanistically and structurally unrelated to the functionally analogous human enzyme, thus providing means for selective inhibition of bacterial growth. To identify novel compounds with anti-bacterial activity against the human pathogenic bacterium...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Open Biol
Главные авторы: Skouloubris, Stéphane, Djaout, Kamel, Lamarre, Isabelle, Lambry, Jean-Christophe, Anger, Karine, Briffotaux, Julien, Liebl, Ursula, de Reuse, Hilde, Myllykallio, Hannu
Формат: Artigo
Язык:Inglês
Опубликовано: The Royal Society 2015
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4632503/
https://ncbi.nlm.nih.gov/pubmed/26040760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.150015
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы