Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer medicines. Cancer cell-line (CCL) profiling of small-molecule sensitivity has emerged as an unbiased method to assess the relationships between gen...

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Udgivet i:Cancer Discov
Main Authors: Seashore-Ludlow, Brinton, Rees, Matthew G., Cheah, Jaime H., Cokol, Murat, Price, Edmund V., Coletti, Matthew E., Jones, Victor, Bodycombe, Nicole E., Soule, Christian K., Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J., Kuru, Nurdan, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A., Palmer, Michelle, Bradner, James E., Shamji, Alykhan F., Clemons, Paul A., Schreiber, Stuart L.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4631646/
https://ncbi.nlm.nih.gov/pubmed/26482930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0235
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