Correlating chemical sensitivity and basal gene expression reveals mechanism of action

Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-mo...

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Bibliographic Details
Published in:Nat Chem Biol
Main Authors: Rees, Matthew G., Seashore-Ludlow, Brinton, Cheah, Jaime H., Adams, Drew J., Price, Edmund V., Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E., Jones, Victor L., Bodycombe, Nicole E., Soule, Christian K., Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D., Hon, C. Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A., Clish, Clary B., Bittker, Joshua A., Palmer, Michelle, Wagner, Bridget K., Clemons, Paul A., Shamji, Alykhan F., Schreiber, Stuart L.
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718762/
https://ncbi.nlm.nih.gov/pubmed/26656090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1986
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