Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease

The inflammatory mediator high-mobility group box 1 (HMGB1) plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). However, the regulation of HMGB1 in NAFLD, particularly through sirtuin 1 (SIRT1), remains unclear. In this study, we investigated the role of SIRT1-med...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Zeng, Wenjing, Shan, Wen, Gao, Lili, Gao, Dongyan, Hu, Yan, Wang, Guangzhi, Zhang, Ning, Li, Zhenlu, Tian, Xiaofeng, Xu, Wei, Peng, Jinyong, Ma, Xiaochi, Yao, Jihong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630617/
https://ncbi.nlm.nih.gov/pubmed/26525891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16013
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