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A Long-Lived Fe(III)-(Hydroperoxo) Intermediate in the Active H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Characterization by Mössbauer, Electron Paramagnetic Resonance, and Density Functional Theory Methods

The extradiol-cleaving dioxygenase homoprotocatechuate 2,3-dioxygenase (HPCD) binds substrate homoprotocatechuate (HPCA) and O(2) sequentially in adjacent ligand sites of the active site Fe(II). Kinetic and spectroscopic studies of HPCD have elucidated catalytic roles of several active site residues...

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Publicat a:Inorg Chem
Autors principals: Meier, Katlyn K., Rogers, Melanie S., Kovaleva, Elena G., Mbughuni, Michael M., Bominaar, Emile L., Lipscomb, John D., Münck, Eckard
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630108/
https://ncbi.nlm.nih.gov/pubmed/26485328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.5b01576
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