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The kinetochore encodes a mechanical switch to disrupt spindle assembly checkpoint signaling

The Spindle Assembly Checkpoint (SAC) is a unique signaling mechanism that responds to the state of attachment of the kinetochore to spindle microtubules. SAC signaling is activated by unattached kinetochores, and it is silenced after these kinetochores form end-on microtubule attachments. Although...

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Publicado en:Nat Cell Biol
Main Authors: Aravamudhan, Pavithra, Goldfarb, Alan A., Joglekar, Ajit P.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630029/
https://ncbi.nlm.nih.gov/pubmed/26053220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3179
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