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The p53 protein is an unusually shaped tetramer that binds directly to DNA.

We have analyzed the size and structure of native immunopurified human p53 protein. By using a combination of chemical crosslinking, gel filtration chromatography, and zonal velocity gradient centrifugation, we have determined that the predominant form of p53 in such preparations is a tetramer. The...

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Autores principales: Friedman, P N, Chen, X, Bargonetti, J, Prives, C
Formato: Artigo
Lenguaje:Inglês
Publicado: 1993
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC46291/
https://ncbi.nlm.nih.gov/pubmed/8475074
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