The p53 protein is an unusually shaped tetramer that binds directly to DNA.
We have analyzed the size and structure of native immunopurified human p53 protein. By using a combination of chemical crosslinking, gel filtration chromatography, and zonal velocity gradient centrifugation, we have determined that the predominant form of p53 in such preparations is a tetramer. The...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1993
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46291/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8475074/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.8.3319 |
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