Genetic and Morphological Features of Human iPSC-Derived Neurons with Chromosome 15q11.2 (BP1-BP2) Deletions

BACKGROUND: Copy number variation on chromosome 15q11.2 (BP1-BP2) causes a deletion of CYFIP1, NIPA1, NIPA2 and TUBGCP5. Furthermore, it also affects brain structure and elevates the risk for several neurodevelopmental disorders that are associated with dendritic spine abnormalities. In rodents, alt...

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Détails bibliographiques
Publié dans:Mol Neuropsychiatry
Auteurs principaux: Das, Dhanjit K., Tapias, Victor, D'Aiuto, Leonardo, Chowdari, Kodavali V., Francis, Lily, Zhi, Yun, Ghosh, Ayantika, Surti, Urvashi, Tischfield, Jay, Sheldon, Michael, Moore, Jennifer C., Fish, Ken, Nimgaonkar, Vishwajit L.
Format: Artigo
Langue:Inglês
Publié: S. Karger AG 2015
Sujets:
Preliminary Study
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4627696/
https://ncbi.nlm.nih.gov/pubmed/26528485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000430916
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