iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections

[Image: see text] The Amaryllidaceae alkaloid trans-dihydrolycoricidine 7 and three analogues 8–10 were produced via asymmetric chemical synthesis. Alkaloid 7 proved superior to acyclovir, the current standard for herpes simplex virus, type 1 (HSV-1) infection. Compound 7 potently inhibited lytic HS...

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Publicat a:ACS Med Chem Lett
Autors principals: McNulty, James, D’Aiuto, Leonardo, Zhi, Yun, McClain, Lora, Zepeda-Velázquez, Carlos, Ler, Spencer, Jenkins, Hilary A., Yee, Michael B., Piazza, Paolo, Yolken, Robert H., Kinchington, Paul R., Nimgaonkar, Vishwajit L.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2015
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4716588/
https://ncbi.nlm.nih.gov/pubmed/26819664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00318
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