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Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog Signaling
Hedgehog (Hh) signaling plays essential roles in animal development and tissue homeostasis, and its misregulation causes congenital diseases and cancers. Regulation of the ubiquitin/proteasome-mediated proteolysis of Ci/Gli transcription factors is central to Hh signaling, but whether deubiquitinase...
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| Publié dans: | Dev Cell |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4627479/ https://ncbi.nlm.nih.gov/pubmed/26120032 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2015.05.016 |
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