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Phosphorylation of Ci/Gli by Fused family kinases promotes Hedgehog signaling
Hedgehog (Hh) signaling culminates in the conversion of the latent transcription factor Cubitus interruptus (Ci)/Gli into its activator form (Ci(A)/Gli(A)), but the underlying mechanism remains poorly understood. Here we demonstrate that Hh stimulates the phosphorylation of Ci by the Ser/Thr kinase...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736714/ https://ncbi.nlm.nih.gov/pubmed/31279575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.06.008 |
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