Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes

Type III secretion system (T3SS) in Pseudomonas aeruginosa is associated with poor clinical outcome in acute infections. T3SS allows for injection of bacterial exotoxins (e.g. ExoU or ExoS) into the host cell, causing cytotoxicity. It also activates the cytosolic NLRC4 inflammasome, activating caspa...

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Detalhes bibliográficos
Publicado no:Pathog Dis
Main Authors: Anantharajah, Ahalieyah, Buyck, Julien M., Faure, Emmanuel, Glupczynski, Youri, Rodriguez-Villalobos, Hector, De Vos, Daniel, Pirnay, Jean-Paul, Bilocq, Florence, Guery, Benoît, Tulkens, Paul M., Mingeot-Leclercq, Marie-Paule, Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Short Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626600/
https://ncbi.nlm.nih.gov/pubmed/26203053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftv049
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