Salicylidene Acylhydrazides and Hydroxyquinolines Act as Inhibitors of Type Three Secretion Systems in Pseudomonas aeruginosa by Distinct Mechanisms

Type 3 secretion systems (T3SSs) are major virulence factors in Gram-negative bacteria. Pseudomonas aeruginosa expresses two T3SSs, namely, an injectisome (iT3SS) translocating effector proteins in the host cell cytosol and a flagellum (fT3SS) ensuring bacterial motility. Inhibiting these systems is...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Anantharajah, Ahalieyah, Buyck, Julien M., Sundin, Charlotta, Tulkens, Paul M., Mingeot-Leclercq, Marie-Paule, Van Bambeke, Françoise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444141/
https://ncbi.nlm.nih.gov/pubmed/28396545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02566-16
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