RX-P873, a Novel Protein Synthesis Inhibitor, Accumulates in Human THP-1 Monocytes and Is Active against Intracellular Infections by Gram-Positive (Staphylococcus aureus) and Gram-Negative (Pseudomonas aeruginosa) Bacteria

The pyrrolocytosine RX-P873, a new broad-spectrum antibiotic in preclinical development, inhibits protein synthesis at the translation step. The aims of this work were to study RX-P873's ability to accumulate in eukaryotic cells, together with its activity against extracellular and intracellula...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Buyck, Julien M., Peyrusson, Frédéric, Tulkens, Paul M., Van Bambeke, Françoise
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505283/
https://ncbi.nlm.nih.gov/pubmed/26014952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00428-15
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