Study of Macrophage Functions in Murine J774 Cells and Human Activated THP-1 Cells Exposed to Oritavancin, a Lipoglycopeptide with High Cellular Accumulation

Oritavancin, a lipoglycopeptide antibiotic in development, accumulates to high levels in the lysosomes of eukaryotic cells. We examined specific functions of macrophages (phagocytic capacity, lysosomal integrity, metabolic activity, and production of reactive oxygen species [ROS]) in correlation wit...

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Bibliografiske detaljer
Main Authors: Lemaire, Sandrine, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M., Van Bambeke, Françoise
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023769/
https://ncbi.nlm.nih.gov/pubmed/24449768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02475-13
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