Study of Macrophage Functions in Murine J774 Cells and Human Activated THP-1 Cells Exposed to Oritavancin, a Lipoglycopeptide with High Cellular Accumulation

Oritavancin, a lipoglycopeptide antibiotic in development, accumulates to high levels in the lysosomes of eukaryotic cells. We examined specific functions of macrophages (phagocytic capacity, lysosomal integrity, metabolic activity, and production of reactive oxygen species [ROS]) in correlation wit...

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Hlavní autoři: Lemaire, Sandrine, Mingeot-Leclercq, Marie-Paule, Tulkens, Paul M., Van Bambeke, Françoise
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023769/
https://ncbi.nlm.nih.gov/pubmed/24449768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02475-13
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