Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes

Type III secretion system (T3SS) in Pseudomonas aeruginosa is associated with poor clinical outcome in acute infections. T3SS allows for injection of bacterial exotoxins (e.g. ExoU or ExoS) into the host cell, causing cytotoxicity. It also activates the cytosolic NLRC4 inflammasome, activating caspa...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pathog Dis
Prif Awduron: Anantharajah, Ahalieyah, Buyck, Julien M., Faure, Emmanuel, Glupczynski, Youri, Rodriguez-Villalobos, Hector, De Vos, Daniel, Pirnay, Jean-Paul, Bilocq, Florence, Guery, Benoît, Tulkens, Paul M., Mingeot-Leclercq, Marie-Paule, Van Bambeke, Françoise
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2015
Pynciau:
Short Communication
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626600/
https://ncbi.nlm.nih.gov/pubmed/26203053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftv049
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