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Mechanism of quinine-dependent monoclonal antibody binding to platelet glycoprotein IIb/IIIa

Drug-dependent antibodies (DDAbs) that cause acute thrombocytopenia upon drug exposure are nonreactive in the absence of the drug but bind tightly to a platelet membrane glycoprotein, usually α(IIb)/β(3) integrin (GPIIb/IIIa) when the drug is present. How a drug promotes binding of antibody to its t...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Bougie, Daniel W., Peterson, Julie, Rasmussen, Mark, Aster, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4626255/
https://ncbi.nlm.nih.gov/pubmed/26353910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-04-643148
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