Quinine-dependent, platelet-reactive monoclonals mimic antibodies found in patients with quinine-induced immune thrombocytopenia

Drug-induced immune thrombocytopenia (DITP) is caused by drug-dependent antibodies (DDAbs) that are nonreactive in themselves but bind tightly to specific platelet membrane glycoproteins (GP) when soluble drug is present at pharmacologic concentrations. This reaction takes place without covalent lin...

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Main Authors: Bougie, Daniel W., Birenbaum, Jessica, Rasmussen, Mark, Poncz, Mortimer, Aster, Richard H.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2009
Teme:
Platelets and Thrombopoiesis
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635075/
https://ncbi.nlm.nih.gov/pubmed/18948570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-09-177279
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