Heparin-independent, PF4-dependent binding of HIT antibodies to platelets: implications for HIT pathogenesis

Antibodies specific for platelet factor 4 (PF4)/heparin complexes are the hallmark of heparin-induced thrombocytopenia and thrombosis (HIT), but many antibody-positive patients have normal platelet counts. The basis for this is not fully understood, but it is believed that antibodies testing positiv...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Padmanabhan, Anand, Jones, Curtis G., Bougie, Daniel W., Curtis, Brian R., McFarland, Janice G., Wang, Demin, Aster, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281824/
https://ncbi.nlm.nih.gov/pubmed/25342714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-06-580894
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