Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Cines, Douglas B., Yarovoi, Serge V., Zaitsev, Sergei V., Lebedeva, Tatiana, Rauova, Lubica, Poncz, Mortimer, Arepally, Gowthami M., Khandelwal, Sanjay, Stepanova, Victoria, Rux, Ann H., Cuker, Adam, Guo, Cecilia, Ocariza, Linnette Mae, Travers, Richard J., Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Conway, Edward M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744055/
https://ncbi.nlm.nih.gov/pubmed/29296696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000877
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