Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia

Heparin-induced thrombocytopenia (HIT) is a thrombotic disorder initiated by antibodies to complexes between platelet factor 4 (PF4) and heparin. The risk of recurrent thromboembolism persists after heparin is cleared and platelet activation leading to release of PF4 has dissipated. We asked whether...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Blood Adv
Prif Awduron: Cines, Douglas B., Yarovoi, Serge V., Zaitsev, Sergei V., Lebedeva, Tatiana, Rauova, Lubica, Poncz, Mortimer, Arepally, Gowthami M., Khandelwal, Sanjay, Stepanova, Victoria, Rux, Ann H., Cuker, Adam, Guo, Cecilia, Ocariza, Linnette Mae, Travers, Richard J., Smith, Stephanie A., Kim, Hugh, Morrissey, James H., Conway, Edward M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Hematology 2016
Pynciau:
Platelets and Thrombopoiesis
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5744055/
https://ncbi.nlm.nih.gov/pubmed/29296696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016000877
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